![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Morin, a Polypharmacological Marvel: Unveiling its versatility and recent advances in bioavailability enhancement
Vani, Vijay and Madan Kumar, Perumal (2025) Morin, a Polypharmacological Marvel: Unveiling its versatility and recent advances in bioavailability enhancement. Food Bioscience, 65. pp. 1-13.
![[img]](http://ir.cftri.res.in/style/images/fileicons/other.png) |
PDF
1-s2.0-S2212429225002809-main.pdf - Published Version Restricted to Registered users only Download (4MB) | Request a copy |
Abstract
Morin, a flavonoid present in many fruits and plants, exhibit a broad range of pharmacological effects including antioxidant, anti-diabetic, cardioprotective, hepatoprotective, neuroprotective, anti-fibrotic, anti-cancer, etc. Morin is widely used in pre-clinical research however the clinical application of morin is impeded by its poor water solubility and restricted oral bioavailability. Application of methods including encapsulation, complexa tion, particle size reduction could help in enhancement of water solubility and oral bioavailability of morin. In this review, the factors affecting the solubility and oral bioavailability of morin and strategies for enhancing morin’s solubility and bioavailability were discussed. A vast number of studies showed the solubility and oral bioavailability of morin could be significantly improved by the encapsulation, inclusion complexation, particle size reduction methods and controlled delivery systems. Each of the method has its advantages and limitations, and the specific selection should be based on the application domains. The findings highlighted the importance of using novel methods to overcome the limitations of morin to improve its therapeutic potential.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Morin Nutraceutical Solubility Oral bioavailability Encapsulation Inclusion complex |
| Subjects: | 500 Natural Sciences and Mathematics > 10 Plants 600 Technology > 01 Medical sciences > 15 Pharmacology |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Somashekar K S |
| Date Deposited: | 06 Mar 2025 06:20 |
| Last Modified: | 06 Mar 2025 06:20 |
| URI: | http://ir.cftri.res.in/id/eprint/19219 |
Actions (login required)
 |
View Item |