N-glycoprofiling of lactoferrin with site-specificity from buffalo colostrum

Gnanesh Kumar, B. S. and Lijina, P. and Akshata, S. H. (2022) N-glycoprofiling of lactoferrin with site-specificity from buffalo colostrum. International Dairy Journal, 127. pp. 1-5.

PDF 1-s2.0-S0958694621002430-main.pdf - Published Version Restricted to Registered users only Download (708kB) | Request a copy

Abstract

Lactoferrin (Lf) from buffalo colostrum was probed for N-glycan diversity and abundances that were previously unknown. Out of four N-glycosylation sites present, two sites, N233NT and N545DT, exhibited predominantly high-mannose glycans. Site N281 KS showed mainly sialylated hybrid types. A higher abundance of differentially sialylated hybrid glycans was present at N476QT. In addition, the genetic variant of Lf was identified. Overall, this study showed that high mannose and hybrid types are the major glycans in Lf from buffalo colostrum.

Item Type:	Article
Uncontrolled Keywords:	N-glycoprofiling, lactoferrin, buffalo colostrum
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology 600 Technology > 08 Food technology > 27 Dairy products
Divisions:	Dept. of Biochemistry
Depositing User:	Somashekar K S
Date Deposited:	19 Dec 2025 04:37
Last Modified:	19 Dec 2025 04:37
URI:	http://ir.cftri.res.in/id/eprint/20203

Actions (login required)

View Item