Absorption and tissue distribution of curcumin in rats.

Vijayalakshmi, R. and Chandrashekara, N. (1980) Absorption and tissue distribution of curcumin in rats. Toxicology, 16. pp. 259-265.

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Abstract

After oral administration of 400 mg curcumin to rats, about 60% of the dose was absorbed. No curcumin was detectable in urine. The urinary excretion of conjugated glucuronides and sulfates significantly increased. No curcumin was present in heart blood. Only traces (less than 5 ~g/ml) in portal blood and negligible quantities in liver and kidney (<~ 20 ~g/tissue) were observed from 15 rain upto 24 h after administration of curcumin. At the end of 24 h the concentration of curcumin remaining in the lower part of the gut namely caecum and large intestine amounted to 38% of the quantity administered.

Item Type:	Article
Uncontrolled Keywords:	Turmeric, Curcuma longa, hypocholesteremic effect, chromosomal aberrations
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments 600 Technology > 01 Medical sciences > 09 Human Physiology
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	17 Jun 2011 09:20
Last Modified:	09 May 2012 04:16
URI:	http://ir.cftri.res.in/id/eprint/2632

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