Modification in the acute oral toxicity of zinc phosphide due to isolation stress in the laboratory rat (Rattus norvegicus albino).

Muktha Bai, K. and Yashoda Urs, L. (1995) Modification in the acute oral toxicity of zinc phosphide due to isolation stress in the laboratory rat (Rattus norvegicus albino). Pestology, 19 (7). pp. 30-37.

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Abstract

Zinc phosphide is one of the widely used acute rodenticide to combat different rodent pests throughout the world. However, because of its lower LD50 values to most other forms of life, its use has been restricted for indoor purposes. While some factors viz., age, sex, carrier, temperature, protein content of the diet etc. have been found to alter/influence the toxicity of various pesticidal compounds, information regarding the influence of housing condition on the toxic¡ty of chemicals, especially the rodenticides are meagre. Hence, this paper discusses in detail the behavioural responses of the laboratory rat (Rattus norvegicus, albino) bred, reared and housed in different controlled conditions of isolation and groups to the acute oral toxic¡ty of zinc phosphide for the first time. It was observed that the LD50 values obtained were of the order of 21.2 mg/kg body weight and 150 mg/kg body weight for "isolated" and "group housed" rats respectively indicating the influence of "isolation stress" in the test rodent. Further, observations on behaviour also pointed out that the acute oral toxic¡ty of Zinc phosphide could be modified depending upon the housing pattern and also their breeding environment prior to their use.

Item Type:	Article
Uncontrolled Keywords:	Zinc phosphide, rodenticide, toxicity
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	14 Mar 2012 08:52
Last Modified:	14 Mar 2012 08:52
URI:	http://ir.cftri.res.in/id/eprint/4659

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