Antioxidant activity and hepatoprotective potential of Phyllanthus niruri.

Harish, R. and Shivanandappa, T. (2006) Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chemistry, 95 (1). pp. 180-185. ISSN 0308-8146

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Abstract

Antioxidant activity and hepatoprotective potential of <i>Phyllanthus niruri</i>, a widely used medicinal plant, were investigated. Methanolic and aqueous extract of leaves and fruits of <i>P. niruri</i> showed inhibition of membrane lipid peroxidation (LPO), scavenging of 1,1-diphenyl-2picrylhydrazyl (DPPH) radical and inhibition of reactive oxygen species (ROS) in vitro. Antioxidant activity of the extracts were also demonstrable in vivo by the inhibition of the carbon tetrachloride (CCl₄) – induced formation of lipid peroxides in the liver of rats by pretreatment with the extracts. CCl₄ – induced hepatotoxicity in rats, as judged by the raised serum enzymes, glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT), was prevented by pretreatment with the extracts, demonstrating the hepatoprotective action of <i>P. niruri.</i>

Item Type:	Article
Additional Information:	Copyright of this article belongs to Elsevier.
Uncontrolled Keywords:	Phyllanthus niruri; Antioxidant activity; Lipid peroxidation; Hepatoprotective
Subjects:	600 Technology > 08 Food technology > 32 Antioxidants
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	26 Apr 2007
Last Modified:	28 Dec 2011 09:27
URI:	http://ir.cftri.res.in/id/eprint/538

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