Urinary metabolites of 14C aflatoxin in some laboratory animals.

Shantha, T. and Sreenivasamurthy, V. and Parpia, H. A. B. (1970) Urinary metabolites of 14C aflatoxin in some laboratory animals. Journal of Food Science and Technology, 7. pp. 135-138. ISSN 0022-1155

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Abstract

The quantity of aflatoxin M excreted in the urine of albino rats, guineapigs and monkeys in relation to the administered radio active aflatoxin was determined. 2.5-4.4, 0.15-0.19 and 0.8-1.0 per cent of administered toxin was recovered as aflatoxin M in the urine of albino rats, guineapigs and monkeys, respectively. Nearly 80 per cent of aflatoxin M was excreted within 6 hours after toxin administration. Studies on the absorption of aflatoxin B and M across the intestinal wall showed that aflatoxin B injected into the jejunum in the intact intestines of the anaesthetised rat was absorbed within 15 minutes. Under similar experimental conditions 22 percent of injected aflatoxin M could be recovered from the intestinal lumen. A new flourescent metabolite of aflatoxin released only by perchloric acid hydrolysis was detected in the urine of albino rats and monkeys. Increase in the levels of the administered dose raised the quantity of aflatoxin M in the urine but decreased the levels of unchanged B and the bound fraction. In rats with ligated common bile duct similar alterations had no effect on the excretory pattern of the metabolite.

Item Type:	Article
Uncontrolled Keywords:	Aflatoxin M, urinary metabolite
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	17 May 2012 05:49
Last Modified:	17 May 2012 05:49
URI:	http://ir.cftri.res.in/id/eprint/6155

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