Interaction of piperine with rat liver microsomes.

Ganesh Bhat, B. and Chandrasekhara, N. (1987) Interaction of piperine with rat liver microsomes. Toxicology, 44 (1). 91-98, 23 ref..

PDF Toxicology,_Volume_44,_Issue_1,_April_1987,_Pages_91-98.pdf Restricted to Registered users only Download (710kB)

Abstract

Pretreatment of adult male albino rats with piperine [the major pungent factor of black pepper] did not induce cytochrome P-450 whereas safrole did cause such induction. Piperine and safrole interacted with different forms of cytochrome P-450 as indicated by their in vivo effect on drug metabolising enzymes and mixed function oxidases and electrophoretic patterns. Incubation of piperine or safrole with dithionite- or NADPH-reduced microsomes from untreated rats resulted in a modified type II difference spectrum with an absorption max. at 427 nm and a trough at 408 nm.

Item Type:	Article
Uncontrolled Keywords:	SPICES-; piperine, hepatotoxicity of; pepper, physiological effects of black; ALKALOIDS-; TOXICITY-
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments 600 Technology > 01 Medical sciences > 12 Metabolism
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	17 Jun 2011 09:48
Last Modified:	28 Dec 2011 09:52
URI:	http://ir.cftri.res.in/id/eprint/6308

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