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Growth inhibition of human pro-myelocytic leukemia (HL-60) cells by lipid extracts of marine alga Sargassum marginatum (Fucales, Phaeophyta) harvested off Goa (west coast of India) with special reference to fatty acid composition
Bhaskar, N. and Hosakawa, M. and Miyashita, K. (2004) Growth inhibition of human pro-myelocytic leukemia (HL-60) cells by lipid extracts of marine alga Sargassum marginatum (Fucales, Phaeophyta) harvested off Goa (west coast of India) with special reference to fatty acid composition. Indian Journal of Marine Sciences, 33 (4). pp. 355-360.
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Abstract
The present investigation deals with the fatty acid composition of total lipids and different lipid classes of brown seaweed Sargassum marginatum harvested off Goa. An effort was made to screen the growth inhibitiory/cytotoxic activity of lipid extracts on the human pro-melocytic leukemia (HL-60) cells. Phospholipids (PL) were found to be the most effective compared to the other lipid classes in terms of cytotoxic activity. PL exhibited cytotoxic activity at concentrations as low as 20 μg/ml. Phospholipids were found to be higher in poly unsaturated fatty acids (PUFA) among all the lipid classes analysed. This study indicates the possibility of seaweeds as potential sources of anticancer substances. Further works are needed to identify the active compound responsible for this anti-cancerous activity. The role of non-methylene interrupted (NMI) fatty acid specific to Sargassum spp, as anti-cancerous substance, also needs to be elucidated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Seaweed; Cancer; Phospholipids; PUFA; NMI fatty acid |
| Subjects: | 600 Technology > 08 Food technology > 19 Lipids-oils/fats 500 Natural Sciences and Mathematics > 08 Botanical sciences > 01 Botany > 01 Algae |
| Divisions: | Meat Fish and Poultry Technology |
| Depositing User: | Users 197 not found. |
| Date Deposited: | 21 Feb 2011 07:22 |
| Last Modified: | 03 Oct 2018 06:43 |
| URI: | http://ir.cftri.res.in/id/eprint/9918 |
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