Antiulcer And Anticancer Bioactive Compounds From Ginger (Zingiber Officinale) And Mango Ginger (Curcuma Amada)

Siddaraju, M. N. (2008) Antiulcer And Anticancer Bioactive Compounds From Ginger (Zingiber Officinale) And Mango Ginger (Curcuma Amada). Doctoral thesis, University of Mysore.

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Abstract

Ulcer is a common global problem with increasing incidence and prevalence. Worldwide 14.5 million people have ulcers with a mortality of 4.08 million. The increasing incidence and prevalence of ulcers have been attributed to several factors encountered during day-to-day life, such as stress, exposure to bacterial infection, and use of non-steroidal anti-inflammatory drugs (NSAIDS). Ulcers are resulted from excess secretion of hydrochloric acid from gastric parietal cells via activation of H+ , K+-ATPase enzyme, which releases the H+ into the lumen of the stomach leading to acidity and the released acid act on gastric mucosa leading to loss of mucosal protection. Gastric lesions thus develop due to loss of the delicate balance between gastro-protective and aggressive factors. Reduction in gastric mucin, enhanced secretion of gastric acid from parietal cells, enhanced susceptibility to Helicobacter pylori infection aggravates the ulcer pathogenicity leading to severe gastric ulcers with heavy bleeding, erosions, etc. Accumulated literature suggests that alcohol also play a major role in causing gastric ulcers via portal hypertension. Further, long term ulcers were found to lead to cancers. Sustainable efforts and constant research in the area lead to the development of several drugs that can act at multi-steps during ulcer pathogenicity such as proton pump blockers (Lansoprazole, Omeprazole), histamine receptor blockers (Ranitidine, Cimetidine, Famotidine) and H. pylori Inhibitors (Amoxicillin, Erythromycin, Metronidazole), However, majority of them have been documented with the pose of adverse effects. Abstract  vi In light of the above, it is pertinent to study natural products from food/plants as potentials antiulcer compounds. In the current thesis therefore dietary components have been explored as a potential effective and safer antiulcer compounds. Since stress induction has been known to cause ulcer as well as cancers via free radical induced reactive oxygen species leading to both nuclear and cellular damages, dietary sources rich in antioxidative properties have been selected. Ginger (Zingiber officinale) and Mango ginger (Curcuma amada) have been known to exhibit potential health beneficial properties against various disorders in traditional medicine. Accordingly antiulcer and anticancer compounds have been addressed from ginger and mango ginger by proposing the research topic entitled “Antiulcer and anticancer bioactive compounds from ginger (Zingiber officinale) and mango ginger (Curcuma amada)”. Results of the study suggested the role of antioxidants, particularly phenolic acids and pectic polysaccharides that are effective in prevention and healing of ulcers at multi-steps of ulcer pathogenicity as indicated in Scheme -1. Fractions of ginger and mango ginger showed multipotent antiulcer (Chapter 2 & 3) and anticancer (Chapter 4) properties including inhibition of H+ , K+-ATPase, inhibition of H. pylori growth, exhibiting antioxidant, antiproliferative and DNA protective potentials. Thus antioxidant and pectic polysaccharide fractions of ginger and mango ginger have been found to be effective antiulcer/anticancer alternatives

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	Ulcer, Ginger, Mango ginger, health beneficial properties, pectic polysaccharide
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments 600 Technology > 08 Food technology > 32 Antioxidants
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	01 Mar 2011 11:14
Last Modified:	22 Oct 2018 06:11
URI:	http://ir.cftri.res.in/id/eprint/9957

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