Alterations in Intestinal Microflora in the Terramycin-fed Rat.

Alterations in morphological characteristics and metabolic activities of coliforms
isolated from faeces of rats fed terramycin over a long period have been studied.
Coliforms from terramycin-fed group show tolerance to the antibiotic; those from
vitamins-supplemented group also exhibit tolerance though to a lesser degree. No
noticeable effect of in vitro addition of vitamins on growth is observable. Coliforms
from antibiotic-fed group have lower capacity to utilize pyruvate and glucose;
those from the group fed the antibiotic with vitamins show enhanced oxygen uptake
with several tricarboxylic acid cycle intermediates.