Bharathi, S. G. and Parvathy, K. S. and Srinivas, P. and Indi, S. S. and Rao, K. S. (2012) Curcumin-glucoside, A Novel Synthetic Derivative of Curcumin, Inhibits alpha-Synuclein Oligomer Formation: Relevance to Parkinson’s Disease. Current Pharmaceutical Design, 18. pp. 76-84.
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Abstract
alpha-Synuclein aggregation is centrally implicated in Parkinson’s disease (PD). It involves multi-step nucleated polymerization
process via the formation of dimers, soluble toxic oligomers and insoluble fibrils. In the present study, we synthesized a novel compound
viz., Curcumin-glucoside (Curc-gluc), a modified form of curcumin and studied its anti-aggregating potential with alpha-synuclein. Under
aggregating conditions in vitro, Curc-gluc prevents oligomer formation as well as inhibits fibril formation indicating favorable
stoichiometry for inhibition. The binding efficacies of Curc-gluc to both
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Alpha-synuclein, Parkinson’s disease, curcumin-glucoside, oligomer, aggregation |
| Subjects: | 600 Technology > 01 Medical sciences 600 Technology > 08 Food technology > 30 Spices/Condiments |
| Divisions: | Dept. of Biochemistry Plantation Products Spices and Flavour Technology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 11 Mar 2013 05:48 |
| Last Modified: | 11 Mar 2013 05:48 |
| URI: | http://ir.cftri.res.in/id/eprint/11140 |
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