Enzyme Catalyzed Synthesis of Serotonyl and Epinephryl Glycosides Using Amyloglucosidase from Rhizopus Mold.

Ganesan, V. and Divakar, S. (2011) Enzyme Catalyzed Synthesis of Serotonyl and Epinephryl Glycosides Using Amyloglucosidase from Rhizopus Mold. Indian Journal of Fundamental and Applied Life Sciences, 1 (2). pp. 15-21. ISSN 2231-6345

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Abstract

Glycosylation of phenolic hydroxyl groups of serotonin and epinephrine, using an amyloglucosidase from Rhizopus mold was carried out with D-glucose, D-galactose, D-mannose and D-ribose in di-isopropyl ether solvent to yield 13-29% of glycosides in 48h. NMR spectroscopic data indicated that the reaction occurred between the phenolic -OH group of serotonin and C1α /β and / or 6-O-groups of D-glucose, D-galactose, D-mannose and D-ribose. In case of epinephrine, 4 –OH and 3 –OH groups reacted with C1 β anomer of D-glucose and C-1 α/β anomers of D-mannose.

Item Type:	Article
Uncontrolled Keywords:	Amyloglucosidase, glycosylation, Epinephrine, Serotonin, 6-O arylation, Selectivity
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 16 Enzyme Chemistry
Divisions:	Fermentation Technology and Bioengineering
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	12 Jan 2015 05:59
Last Modified:	12 Jan 2015 05:59
URI:	http://ir.cftri.res.in/id/eprint/11706

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