Ravi, H. (2016) Polymer-lipid nanocarriers to improve stability, bioavailability and anti-cancer property of carotenoid fucoxanthin. Doctoral thesis, Central Food Technological Research Institute.
![[thumbnail of Ravi.pdf]](http://ir.cftri.res.in/style/images/fileicons/other.png "Ravi.pdf")
PDF
Ravi.pdf - Submitted Version
Restricted to Repository staff only
Download (10MB)
Abstract
Fucoxanthin (FUCO), a xanthophyll carotenoid is photo-, and thermo-labile and
poorly bioavailable due to its lipophilicity. Stability and bioavailability of FUCO can be
improved by its encapsulation with a suitable polymer matrix and specific lipid. Hence,
nanoencapsulated FUCO was prepared using chitosan (CS) - sodium tripolyphosphate
(TPP) - glycolipid (GL) multifaceted system (CS-NGs) by means of ionic gelation
method. It was hypothesized that nanoencapsulated FUCO in CS-NGs+GL matrix may
favour its intestinal uptake and intracellular trafficking with no toxicity. It was aimed that
GL and FUCO may be an agonist to PPARγ and SRB1 which may result in active
intestinal uptake of FUCO besides passive uptake.
| Item Type: | Thesis (Doctoral) |
|---|---|
| Uncontrolled Keywords: | Fucoxanthin chitosan carotenoids anticancer |
| Subjects: | 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 13 Jul 2017 06:59 |
| Last Modified: | 13 Jul 2017 06:59 |
| URI: | http://ir.cftri.res.in/id/eprint/12815 |
Actions (login required)
- View Item