Neuropeptide Y structure is modulated by aluminium in the hypothalamus.

Jagannatha Rao, K. S. and Ramesh, J. and Easwaran, K. R. (1999) Neuropeptide Y structure is modulated by aluminium in the hypothalamus. Alzheimer's Reports, 2 (2). pp. 99-103.

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Abstract

Aluminium is an element suspected to contribute to the pathogenesis of Alzheimer's dise<.lse, but its mechanism of action is not clear. Neuropeptide Y (NPY) plays a significant role in feeding behaviour. Our spectroscopic, ELISA, and western blot studies indicate that aluminium interacts with neuropeptide Y and alters significantly the a-helical content. We found that aluminium reduced levels of NPY in the hypothalamus of aged rabbits. NPY polyclonal antibody interaction was found to depend upon the ahelical content of NPY. These results clearly show that aluminium alters NPY structure and this could explain the abnormality in feeding behaviour seen in patients with Alzheimer's disease.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer's disease, Neuropeptide Y, Aluminium
Subjects:	600 Technology > 01 Medical sciences > 02 Anatomy
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	14 Feb 2018 11:01
Last Modified:	14 Feb 2018 11:01
URI:	http://ir.cftri.res.in/id/eprint/13417

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