Molecular Understanding of Aluminum Bioinorganic Chemistry in Relevance to the Pathology of Alzheimer's Disease.

Aluminum (Al) is a suspected etiological factor in neurological
disorders like Alzheimer's, Parkinson's, Huntington's diseases
etc. The understanding of Al neurobiochemistry was hampered
due to Al speciation chemistry and differential sensitivity
animal models for Al toxicity. Experimental and circumstantial
evidence provided a great deal of information on the complex
inorganic biochemistry of Al in relevance to pathological events
observed in Alzheimer's brains. In this contribution, the
speciation chemistry of Al in relevance to neurobiology, role of
Al, in modulating trace elemental homeostasis in human brains,
Al-induced changes in animal brains mimicking Alzheimer's
human brains, and its interaction with DNA are discussed.