Withaferin-A down-regulate enterohepatic circulation of bile acids: An insight from a hyperlipidemic rat model.

Pooja, Acharya and Parvati, H. and Sadashivaiah, B. and Mehrdad, Zarei and Vinayak, Uppin and Nayana, Venugopal and Ramaprasad, T. R. (2020) Withaferin-A down-regulate enterohepatic circulation of bile acids: An insight from a hyperlipidemic rat model. Journal of Agriculture and Food Research, 2. pp. 1-6.

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Abstract

Hyperlipidemia is a metabolic abnormality in both young and aged populations across the world. Withaferin-A (WT) present in Withania somnifera (Indian ginseng) has been studied by many investigators for their therapeutic potentials. However, their effects on bile acid (BA) metabolism, that play a significant role in lipid homeostasis under hyperlipidemia has not been studied. This study explores the modulatory potential of WT on BA metabolism in young and aged hyperlipidemic rats. Hyperlipidemia was induced by feeding lard fat (35g/100g diet, HF) for 60 days. Withaferin-A (2.5 mg/kg diet) was fed to assess its effect on lipid metabolism and enterohepatic circulation of BA. In both models, compared to HF, WT had significantly (p < 0.05), decreased serum lipids, BA uptake, and HMG-CoA reductase activity, but increased hepatic Cyp7a1, decreased serum BA and increased fecal BA. WT re-regulated hyperlipidemia-induced aberrations in the intestinal uptake, hepatic synthesis, and cholesterol and BA metabolism in both models.

Item Type:	Article
Uncontrolled Keywords:	Apical sodium-dependent bile acid transporter Cholesterol 7-α hydroxylase HMG-CoA Hyperlipidemia Withaferin-A
Subjects:	600 Technology > 01 Medical sciences > 04 Diabetes Mellitus 600 Technology > 03 Agriculture > 04 Medicinal Plants
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	30 Apr 2020 07:02
Last Modified:	30 Apr 2020 07:02
URI:	http://ir.cftri.res.in/id/eprint/14275

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