Potential Anti-Mycobacterium tuberculosis Activity of Plant Secondary Metabolites: Insight with Molecular Docking Interactions.

Tuberculosis (TB) is a recurrent and progressive disease, with high mortality rates worldwide.
The drug-resistance phenomenon of Mycobacterium tuberculosis is a major obstruction of
allelopathy treatment. An adverse side effect of allelopathic treatment is that it causes serious health
complications. The search for suitable alternatives of conventional regimens is needed, i.e., by
considering medicinal plant secondary metabolites to explore anti-TB drugs, targeting the action
site of M. tuberculosis. Nowadays, plant-derived secondary metabolites are widely known for their
beneficial uses, i.e., as antioxidants, antimicrobial agents, and in the treatment of a wide range of
chronic human diseases (e.g., tuberculosis), and are known to “thwart” disease virulence. In this
regard, in silico studies can reveal the inhibitory potential of plant-derived secondary metabolites
against Mycobacterium at the very early stage of infection. Computational approaches based on
different algorithms could play a significant role in screening plant metabolites against disease
virulence of tuberculosis for drug designing.