Impact of phenolic concentrate from tender coconut water and coconut testa on high fat cholesterol fed C57BL6 mice.

Coconut testa and tender coconut water (TCW)
are by-products of coconut processing industries which are
rich in natural phytonutrients, if not exploited properly it
may add up to environmental pollution. In the current
study, phenolic concentrate (PHE) from coconut testa and
tender coconut water (TCW) concentrates were examined
for their effect on high fat fed C57BL/6 mice at the level
of 50 & 100 mg and 500 & 1000 mg/kg body weight
respectively. Results showed increasing body weight in
high fat fed animals when compared to starch fed control
(ND/SFD) group. Treatment with concentrates of PHE and
TCW reduced their body weight dose dependently. Lipid
profile like triglycerides, cholesterol and LDL levels were
significantly decreased, whereas HDL levels increased,
indicating its health beneficial effect. Catalase, SOD, GPx,
TBARS in tissues, analysis of OGTT, serum insulin levels,
advance glycation and atherogenic protection were augmented
at different levels in the treated groups. In conclusion,
phenolic concentrate prepared from the coconut
testa and tender coconut water concentrate revealed their
hypolipidemic property which can be exploited further in
the development of health foods.