Selective Homodecoupled 1D‑ 1 H NMR Experiment for Unravelling Enantiomers.

Naresh, K. S. and Theerthan, N. Kumar and Siva Sankara Reddy, Singam and Sachin, R. Chaudhari (2022) Selective Homodecoupled 1D‑ 1 H NMR Experiment for Unravelling Enantiomers. Analytical Chemistry, 94. pp. 10299-10303.

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Abstract

: 1 H NMR spectroscopy is a quick and easy tool to resolve enantiomers. However, the paradigm of resolution of enantiomers by 1 H NMR is a difficult task due to the minor chemical shift differences and overlap of the resonances of the enantiomers. In the current study, we have performed the conventional selective homodecoupling 1D-1 H NMR experiment to achieve chiral resolutions. The predominant features of the proposed methods are (a) high sensitivity as opposed to routinely employed pure shift NMR experiments, (b) easy optimization like conventional 1D-1 H NMR, and (c) an artifact-free spectrum. The application of the method has been exhibited in the measurement of proton chemical shift differences between diastereomers and enantiomer excess (ee). The broad use of the proposed method was demonstrated by employing the six samples utilizing the chiral solvating and derivatizing agents

Item Type:	Article
Uncontrolled Keywords:	enantiomers, g 1D-1H NMR experiment, chiral resolutions
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 04 Analytical Chemistry
Divisions:	Plantation Products Spices and Flavour Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	24 Jan 2023 09:05
Last Modified:	24 Jan 2023 09:05
URI:	http://ir.cftri.res.in/id/eprint/15848

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