Selective Homodecoupled 1D‑ 1 H NMR Experiment for Unravelling Enantiomers.

: 1
H NMR spectroscopy is a quick and easy tool to
resolve enantiomers. However, the paradigm of resolution of
enantiomers by 1
H NMR is a difficult task due to the minor
chemical shift differences and overlap of the resonances of the
enantiomers. In the current study, we have performed the
conventional selective homodecoupling 1D-1
H NMR experiment
to achieve chiral resolutions. The predominant features of the
proposed methods are (a) high sensitivity as opposed to routinely
employed pure shift NMR experiments, (b) easy optimization like
conventional 1D-1
H NMR, and (c) an artifact-free spectrum. The
application of the method has been exhibited in the measurement of proton chemical shift differences between diastereomers and
enantiomer excess (ee). The broad use of the proposed method was demonstrated by employing the six samples utilizing the chiral
solvating and derivatizing agents