A critical review on anti-fibrotic phytochemicals targeting activated hepatic stellate cells.

Nivya, V. and Madan Kumar, P. (2022) A critical review on anti-fibrotic phytochemicals targeting activated hepatic stellate cells. Journal of Food Biochemistry, 46. e14438. ISSN 1745-4514

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Abstract

Liver fibrosis is a major health concern occurring worldwide. It arises due to prolonged wound healing response of various insults like viral, autoimmune, cholestatic, drug�induced, and metabolic diseases. Currently, there is no clinically approved drug for liver fibrosis treatment. Hepatic stellate cells are the principal liver cells that are activated during liver fibrosis, and targeting these activated cells is an ideal therapeutic strategy. Numerous phytochemicals have been demonstrated in vitro and in vivo treating experi�mental liverfibrosis; however, none of them have been clinically approved fortherapeutic use. This review mainly focuses on such hepatoprotective phytochemicals reported in�hibiting major signaling pathways that are dysregulated in activated hepatic stellate cells. Practical applications Liver fibrosis is a global health concern and there is no FDA approved drug to treat liver fibrosis. Although notable pharmacological agents like pentoxifylline, gliotoxin, imatin�ibmesylate, Gleevec, and so on are reported to exhibit anti-fibrotic effect, the major con�cern is their side effect. Hence, phytochemicals are promising candidates that could be employed against liver fibrosis. In this review, the anti-fibrotic potential of phytochemi�cals targeting activated HSCs are summarized. Understanding these phytochemicals will further help in the development of agents that are more effective against liver fibrosis.

Item Type:	Article
Uncontrolled Keywords:	activation, hepatic stellate cells, hepatoprotective, inhibition, liver fibrosis, phytochemicals, signaling pathways
Subjects:	600 Technology > 01 Medical sciences
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	15 May 2023 09:12
Last Modified:	15 May 2023 09:12
URI:	http://ir.cftri.res.in/id/eprint/16334

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