Maternal omega-3 LC-PUFA supplementation programs an improved bone mass in the offspring with a more pronounced effect in females than males at adulthood.

Sowmya, G. Vamadeva and Kalpana, Platel and Ravi Mangu, S.V.S.S and Govindraj, Ellur and Vijay Sukhdeo, Shinde and Kunal, Sharan (2023) Maternal omega-3 LC-PUFA supplementation programs an improved bone mass in the offspring with a more pronounced effect in females than males at adulthood. Journal of Nutritional Biochemistry, 113. p. 109245.

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Abstract

Early balanced nutrition is vital in achieving optimal skeletal mass and its maintenance. Although a lower omega-6 (n-6): omega-3 (n-3) long-chain polyunsaturated fatty acid (LC-PUFA) ratio is strongly linked with bone health, its maternal effect in the programming of the offspring’s skeleton remains to be elucidated. Plugged C57BL/6 mice were fed either n-3 LC-PUFA Enriched Diet (LED) or a control diet (C) throughout their gestation and lactation. Offspring born to both the groups were weaned onto C till 6, 12, and 24 weeks of their age. Offspring’s skeleton metabolism and serum fatty acid compo�sition was studied. In humans, seventy-five mother-female newborns pairs from term gestation were tested for their maternal LC-PUFA status relationships to venous cord blood bone biomarkers. Offspring of maternal LED supplemented mice exhibited a superior bone phenotype over C, more prominent in females than males. A lower serum n-6/n-3 LC-PUFA in the LED group offspring was strongly associated with blood biomarkers of bone metabolism. Sexual dimorphism evidenced had a strong correlation between offspring’s LC-PUFA levels and bone turnover markers in serum. A higher potential for osteoblastic differentiation in both LED offspring genders and reduced osteoclastogenesis in females was cell-autonomous effect. The human cross-sectional study also showed a positive correlation between maternal n-3 PUFA and cord blood markers of bone formation in female newborns at birth. Maternal dietary n-6/ n-3 fat quality determines offspring’s bone growth and development. Our data suggest that the skeleton of female offspring is likely to be more sensitive to this early exposure

Item Type:	Article
Uncontrolled Keywords:	Maternal nutrition; Omega-3 LC-PUFA; Skeleton; Sexual dimorphism; Developmental origin of health and disease (DoHAD); Metabolic programming; Osteoporosis
Subjects:	600 Technology > 01 Medical sciences > 13 Nutrition-Human
Divisions:	Meat Fish and Poultry Technology Molecular Nutrition
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	16 May 2023 04:55
Last Modified:	16 May 2023 04:55
URI:	http://ir.cftri.res.in/id/eprint/16355

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