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Inhibitory effects of barnyard millet phenolic compounds on the advanced glycation end product formation and diabetic retinopathy.
Mohamed Anis, A. (2022) Inhibitory effects of barnyard millet phenolic compounds on the advanced glycation end product formation and diabetic retinopathy. Doctoral thesis, Central Food Technological Research Institute.
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Abstract
Protein glycation and advanced glycation end products (AGE) generate free radicals via the autoxidation of sugars. Besides, accumulation of these AGE products has been implicated in numerous diabetic complications including neuropathy, nephropathy, retinopathy and cataract. In addition, elevated eye lens aldose reductase (AR) activity, which converts glucose to sorbitol through polyol pathway also results in altered vascular and retinal membrane permeability, accelerated glucose metabolism-associated oxidative stress and cataractogenesis. Therefore, inhibiting the process of protein glycation and AR activity are some of the key strategies adopted to prevent glycation-mediated diabetic complications. In recent years, natural phytochemicals from plants that effectively inhibit glycation with fewer side effects have attracted more and more interest from researchers. Thus, natural protein glycation inhibitors from barnyard millet (Echinochloa frumentacea) could be a more effective strategy to control protein glycoxidation and AGE formation and provide benefits without the side effects associated with synthetic drugs. Hence, this study aimed to evaluate the inhibitory effects of barnyard millet phenolics on sugar-mediated protein glycation, AGEs formation and their protective abilities on protein glycoxidation
| Item Type: | Thesis (Doctoral) |
|---|---|
| Uncontrolled Keywords: | barnyard millet phenolics, functional ingredients, diabetics, diabetic retinopathy, anti-glycation |
| Subjects: | 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus 600 Technology > 08 Food technology > 21 Cereals > 05 Ragi (Finger Millet) |
| Divisions: | Grain Science and Technology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 18 May 2023 09:10 |
| Last Modified: | 18 May 2023 09:10 |
| URI: | http://ir.cftri.res.in/id/eprint/16404 |
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