Combinatorial epigenetic approach against triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer with poor
clinical outcomes. There is no specific targeted therapy available for TNBC patients. Hence, they
undergo standard chemotherapy and encounter early chemoresistance as well as tumor relapse.
Hence, there is a pertinent therapeutic strategy indispensable to facilitating the clinical outcome of
TNBC patients. More recently, combination therapy with bioactive phytochemicals is getting
wider attention not only due to the reduction in the drug-associated toxicity but also the synergism
found with available therapeutics. In the current study, 3, 3’-diindolylmethane (DIM), a dietary
bioactive rich in cruciferous vegetables, has been studied for the synergistic effect with
centchroman (CC), a female oral contraceptive that has been effective against breast cancer. The
results have shown that DIM and CC synergistically inhibited cell proliferation and induced
apoptosis in breast cancer cells.