Taurine Activates SIRT1/AMPK/FOXO1 Signaling Pathways to Favorably Regulate Lipid Metabolism in C57BL6 Obese Mice.

The identification of novel therapeutic agents capable of modulating
lipid metabolism holds a promising potential in combating obesity and its
associated complications. This study is conducted to evaluate the lipid
lowering effect of dietary taurine administration on high-fat fed C57BL6 mice
and to study the mechanism by which taurine impacts lipid metabolism.
Methods and results: C57BL6 mice are grouped into four (n = 6): i) normal
diet (ND), ii) a high-fat diet (HFD), iii) HFD + orlistat (STD), iv) HFD + taurine
(TAU) group for 12 weeks. The results show that taurine administration for 12
weeks reduces high fat-induced weight gain, and liver weight when compared
with HFD fed mice. It also improves serum biochemical parameters like total
cholesterol and triglycerides. Sirtuin 1 (SIRT1) activity, Nicotinamide adenine
dinucleotide (NAD+) levels, SIRT1 mRNA, and protein expression are
increased in HFD + TAU diet group as compared to HFD group. Taurine
treatment suppresses the expression of lipogenic genes (sterol regulatory
element binding protein 1c [SREBP1c], fatty acid synthase [FAS], Peroxisome
proliferator-activated receptor gamma [PPAR