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Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy.
Nimish, Mol Stephen and Deepika, Udayawara Rudresh and Tehreem, Maradagi and Tatsuya, Sugawara and Takashi, Hirata and Ganesan, P. (2023) Insight on the cellular and molecular basis of blood vessel formation: A specific focus on tumor targets and therapy. MedComm – Oncology, 2. e22.
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Abstract
The cellular and molecular switches that govern angiogenesis are considered therapeutic targets for several diseases like tumors and atherosclerosis. Thus, understanding the detailed molecular mechanisms underlying the formation of the new blood vessel is essential for developing novel therapeutic strategies. The formation of a new blood vessel (angiogenesis) is tightly regulated by balancing pro‐ and antiangiogenic molecules. Dysregulated angiogenesis contributes to the pathogenicity of several diseases, including tumors associated with uncontrolled vessel growth. Experimental and clinical studies emphasize that angiogenesis is a critical step for the transition of the tumor to a life‐threatening malignancy. In recent years, angiogenesis has been targeted as one of the primary therapeutic goals for treating tumors, and rapid progress has been made by modulating its molecular regulators. Hence, the mechanisms of how blood vessel formation occurs could provide molecular insight into future angiogenic therapy. This review summarizes briefly the molecular players of blood vessel formation comprising vasculogenesis and angiogenesis and their role in tumor progression alongside antiangiogenic therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | angiogenesis, angiogenic therapy, molecular players, tumor angiogenesis, vasculogenesis |
| Subjects: | 600 Technology > 01 Medical sciences |
| Divisions: | Molecular Nutrition |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 18 Nov 2024 10:56 |
| Last Modified: | 18 Nov 2024 10:56 |
| URI: | http://ir.cftri.res.in/id/eprint/18544 |
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