Synergistic radical scavenging potency of curcumin-in-β-cyclodextrin-in-nanomagnetoliposomes

Aadinath, W. and Anu, Bhushani and Anandharamakrishnan, C. (2016) Synergistic radical scavenging potency of curcumin-in-β-cyclodextrin-in-nanomagnetoliposomes. Materials Science and Engineering C, 64. pp. 293-302.

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Abstract

Curcumin is a highly potent nutraceutical associated with various health benefits. However, its hydrophobic na- ture affects its bioavailability and bioactivity, and limits nutraceutical applications. Drug-in-cyclodextrin-in- liposome has the ability to mask the hydrophobic nature of drug and achieve better encapsulation. Also, encap- sulating iron oxide nanoparticles (IONPs) within liposomes endow additional beneficial functionalities of IONPs. In the present study, curcumin-β-cyclodextrin inclusion complex (IC) and IONPs were co-encapsulated within liposomes (curcumin-in-β-cyclodextrin-in-nanomagnetoliposomes) to achieve the synergistic antioxidant poten- tial of curcumin and IONPs. IC of curcumin-β-cyclodextrin was prepared by a simple rapid method and successful inclusion was confirmed by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). Mean diameter of IONPs was found to be 180 nm and X-ray diffraction pattern confirmed the formation of hematite nanoparticles. Band gap energy calculated using absorption spectra was 2.25 eV, which falls in close proximity with the theoretically calculated values of hematite. Mean diameter of curcumin-in-β-cyclodextrin-in- nanomagnetoliposomes was 67 nm and encapsulation efficiency of curcumin was found to be 71%. Further, the co-encapsulated particles possessed significantly low IC50 value (64.7791 μg/ml, p b 0.01) compared to conventional curcumin liposome and IONPs, indicating its synergistically enhanced radical scavenging property.

Item Type:	Article
Uncontrolled Keywords:	Curcumin, Iron oxide nanoparticles, Inclusion complex, Liposomes, Radical scavenging activity
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 28 Polysaccharide Chemistry 600 Technology > 08 Food technology > 30 Spices/Condiments > 07 Turmeric
Divisions:	Food Engineering
Depositing User:	Somashekar K S
Date Deposited:	11 Mar 2025 06:28
Last Modified:	11 Mar 2025 06:28
URI:	http://ir.cftri.res.in/id/eprint/19256

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