![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Fenugreek-derived exosome-like nanovesicles containing bioavailable phytoferritin for the management of iron deficiency anemia
Cathrine Bethi, M. S. and Meghana Kumar, N. and Sreeram Kalarikkal, P. and Janakiraman, Narayanan and Gopinath Sundaram, M. (2025) Fenugreek-derived exosome-like nanovesicles containing bioavailable phytoferritin for the management of iron deficiency anemia. Journal of Food Chemistry, 490. pp. 1-15.
![[img]](http://ir.cftri.res.in/style/images/fileicons/other.png) |
PDF
1-s2.0-S0308814625023398-main.pdf - Published Version Restricted to Registered users only Download (11MB) | Request a copy |
Abstract
Iron deficiency anemia (IDA) affects 50 % to 60 % of Indian women. Though, iron supplements are often pre scribed, poor bioavailability and side effects limits their use. Phytoferritin, a nanocage containing ~4500 ferric atoms, has been proposed as an alternative, though it’s in vivo bioavailability remains debatable. Plant-derived nanovesicles (PDNVs) are exosome-mimetic vesicles naturally derived from plants. Herein, we demonstrate the presence of phytoferritin nanocages in fenugreek seed PDNVs (FGDNVs). Unlike native pea ferritin (PF), FGDNVs-resident phytoferritin was stable in simulated gastrointestinal digestion. FGDNVs possessed better in vitro bioavailability in Caco-2 and RAW264.7 cells compared to PF. In IDA rats, oral administration of FGDNVs, but not PF, led to stable delivery of phytoferritin in the stomach, duodenum and jejunum tissues. Notably, FGDNVs containing one tenth of recommended dietary allowance of iron, rescued ID and restored hematological parameters. Thus, FGDNVs represent a natural iron nano-formulation for safe and efficient therapeutics for IDA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Exosome-like nanovesicles, Phytoferritin, Iron deficiency anemia, Bioavailability, Iron nano-formulation, fenugreek |
| Subjects: | 600 Technology > 01 Medical sciences > 13 Nutrition-Human 600 Technology > 08 Food technology > 30 Spices/Condiments |
| Divisions: | Molecular Nutrition |
| Depositing User: | Somashekar K S |
| Date Deposited: | 24 Jun 2025 08:20 |
| Last Modified: | 24 Jun 2025 08:20 |
| URI: | http://ir.cftri.res.in/id/eprint/19563 |
Actions (login required)
 |
View Item |