Mango ginger-derived exosome-like nanovesicles promotes diabetic wound healing via inducing the promigratory protein, follistatin-like 1.

Suresh, Anaghapriya and Jahnavi, Ravilla and Narayanan, Janakiraman and Gopinath, M. Sundaram (2025) Mango ginger-derived exosome-like nanovesicles promotes diabetic wound healing via inducing the promigratory protein, follistatin-like 1. International Journal of Biological Macromolecules, 322. pp. 1-14.

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Abstract

Chronic non-healing wounds are major threat in diabetes leading to lower extremity amputation. Lack of ker- atinocyte migration over the wound bed is a causal factor for non-healing wounds. Topical therapeutics with pro- migratory growth factors faces limited success due to the protease rich wound milieu. Plant-derived nanovesicles (PDNVs) are exosome-mimetic vesicles isolated from edible plants with bioavailable presence of several key plant bioactives with therapeutic value. Herein, using in vitro scratch wound model to mimic keratinocyte migration, we screened a panel of seven PDNVs from Zingiberaceae and Citrus plants and found Mango ginger-derived PDNVs (MGDNV) to promote wound healing in vitro. In streptozotocin-induced diabetic mice model, topical application of MGDNVs, formulated as hydrogel, rescued delayed wound healing caused by diabetes. Mecha- nistically, MGDNVs promote keratinocyte migration via induction of follistatin-like 1 (FSTL1) protein both in vitro and in vivo. FSTL1 is a key pro-migratory factor expressed in healing wounds, and failure to induce FSTL1 in keratinocytes leads to lack of cell migration in diabetic wounds. Considering MGDNVs also displayed percutaneous penetration in porcine skin, which is similar to human skin, and exhibited immunomodulatory properties, MGDNVs could be natural and cost-effective topical alternative to conventional biological agents for the treatment of chronic wounds.

Item Type:	Article
Uncontrolled Keywords:	Plant-derived exosome-like nanovesicle, FSTL1, Diabetic ulcer, Topical therapeutic
Subjects:	600 Technology > 01 Medical sciences > 04 Diabetes Mellitus 600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions:	Molecular Nutrition Plantation Products Spices and Flavour Technology
Depositing User:	Somashekar K S
Date Deposited:	12 Nov 2025 11:26
Last Modified:	12 Nov 2025 11:26
URI:	http://ir.cftri.res.in/id/eprint/20086

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