Nanoemulsion-based piperine to enhance bioavailability for the treatment of LPS-induced depression-like behaviour in mice

Shubha, M. Basavaraju and Seema, Mudhol and Muthukumar, Serva Peddha and Shahid Ud, Din Wani and Kamsagara, L. Krishna and Seema, Mehdi and Nabeel, Kinattingal (2023) Nanoemulsion-based piperine to enhance bioavailability for the treatment of LPS-induced depression-like behaviour in mice. Neuroscience Letters, 814. pp. 1-10.

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Abstract

In the present study, the objective was to encapsulate piperine in nanoform by solvent evaporation method and to investigate the antidepressant-like activity of nanopiperine in lipopolysaccharide (LPS) induced depression in mice. LPS-induced depression in mice was reversed by repeated treatment of nanopiperine at dosages of 5 and 10 mg/kg body weight for 14 days. After 24 h of LPS injection, the animals were exposed to a (TST) tail sus- pension test and (FST) forced swim test. A sequence of behaviours was measured on days 0, 7, and 14. On day 14, the animals were euthanized, and the blood was collected; biochemical analysis was performed for the mea- surement of inflammatory and oxidative stress markers. Within the same period, nanopiperine improved hip- pocampal progenitor cell proliferation and increased brain-derived neurotrophic factor (BDNF) levels in the hippocampus of mice subjected to LPS-induced stress. In addition, the neurotransmitter estimation by the HPLC method showed that nanopiperine increased the levels of neurotransmitters. In summary, the nanopiperine showed potent neuroprotective and antidepressant activity, and stability relating to the elevated level of hip- pocampal BDNF level and as compared to pure piperine, the nanopiperine showed better oral bioavailability and stability.

Item Type:	Article
Uncontrolled Keywords:	Depression, Lipopolysaccharide, Nanopiperine, Serotonin, Dopamine, Bioavailability, Catalase, Brain-derived neurotrophic factor
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 18 Phytochemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Somashekar K S
Date Deposited:	19 Dec 2025 05:14
Last Modified:	19 Dec 2025 05:14
URI:	http://ir.cftri.res.in/id/eprint/20179

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