In vitro studies on the intestinal absorption of curcumin in rats.

Vijayalakshmi, R. and Chandrashekara, N. (1981) In vitro studies on the intestinal absorption of curcumin in rats. Toxicology, 20. pp. 251-257.

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Abstract

When everted sacs of rat intestines were incubated with 50--750 ~g of curcumin in 10 ml incubation medium, 30--80% of the added curcumin disappeared from the mucosal side. No curcumin was however detectable in the serosal fluid. Less than 3% of the added curcumin was found in the tissue at the highest concentration. In experiments with [aH]curcumin, 5--6% of added radioactivity was found in the serosal side. TLC examination of the mucosal extract showed the presence of 2 compounds, 1 corresponding to curcumin and the other to a less polar, colourless compound. The serosal fluid had no curcumin but a compound whose RF was identical with the colourless compound present in the mucosal side. These experiments indicated that curcumin undergoes transformation during absorption from the intestine.

Item Type:	Article
Uncontrolled Keywords:	Curcumin, Curcuma longa, rat intestines, absorption of curcumin
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments > 07 Turmeric
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	09 Mar 2011 06:46
Last Modified:	16 May 2012 07:15
URI:	http://ir.cftri.res.in/id/eprint/2418

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