Biochemical changes induced by alpha-naphthylthiourea in albino rats.

Administration of alpha-naphthylthiourea to albino rats caused excessive urinary excretions of
albumin, inorganic phosphorus, and urea in 22 hr. Levels of inorganic phosphorus, glucose, and
creatinine were elevated in blood and in the pleural effusion. Urea contents in blood and pleural
effusion were progressively increased with concomitant rise in arginase activities. Significant
increases were observed in phospholipids, triglycerides, and cholesterol concentrations in blood.
No changes were noticed in cholesterol and fat contents of the liver. Kidney sections showed
lesions in the glomerular region after 8 hr, and in the later stages, the histopathological evidence
was suggestive of acute glomerular nephritis of the lipoidal type.