Lack of genotoxic effects of piperine, (the active principle of black pepper) in albino mice.

Muralidhara, Dr. and Narasimhamurthy, K. (1990) Lack of genotoxic effects of piperine, (the active principle of black pepper) in albino mice. Journal of Food Safety, 11 (1). pp. 39-48.

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Abstract

The potency of piperine, the active principle of black pepper, to induce micronuclei in bone-marrow erythrocytes and dominant-lethal mutations was investigated in male mice. Preliminary studies indicated that piperine administered intraperitoneally to adult male mice at sublethal doses of 1, 2 or 4 mg/kg body wt. (1/20, 1/10 or 1/5 LD50) on 5 consecutive days did not induce any clinical signs of toxicity or any significant alterations in epididymal wt., testicular wt. or testicular histology. In bone-marrow micronucleus assay, piperine induced no significant increase in micronuclei in polychromatic erythrocytes, suggesting its nonclastogenic nature at tested doses. It also failed to induce dominant-lethal mutations during an 8-wk sequential mating schedule of males at a dosage of 4 mg/kg body wt./day for 5 days. Caudal sperm counts and the incidence of sperm-head abnormalities measured at 1, 3, 5 and 7 wk were not altered in piperine administered males at any of the doses.

Item Type:	Article
Uncontrolled Keywords:	ALKALOIDS-; FLAVOUR-COMPOUNDS; FOOD-SAFETY; MUTAGENICITY-; TOXICITY-; GENOTOXICITY-; PIPERINE-
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments 600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Dept. of Biochemistry Food Safety Analytical Quality Control Lab
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	09 Aug 2008 05:58
Last Modified:	03 Oct 2018 09:41
URI:	http://ir.cftri.res.in/id/eprint/8010

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