Counteraction of the toxicity of aflatoxin B1 by thymine and folic acid in experimental animals.

Bhavanishankar, T. N. and Shantha, T. and Ramesh, H. P. (1986) Counteraction of the toxicity of aflatoxin B1 by thymine and folic acid in experimental animals. Nutrition Reports International, 33 (4). pp. 603-612.

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Abstract

Four groups of 6 mice were given a stock diet and 0.2 ml 50% ethanol (control), a single dose of thymine and aflatoxin B1 at 22 or 9 mg/kg bodyweight, (LD50) respectively, or a single dose of a combination of thymine and aflatoxin. Injecting thymine with aflatoxin B1 reduced the mortality from 3 to 1 of 6. In Wistar rats mortality decreased from 5 of 8 when aflatoxin only was injected to 2 and 3 of 8, respectively, when thymine and folic acid were injected with the aflatoxin. Giving aflatoxin B1 in the diet at 5% of LD50 to Wistar rats for 3 months led to marked hypertrophy and hydropic degeneration of the hepatocytes, reduction in liver DNA content and increase in liver weight. Those changes were significantly reduced by giving thymine or a combination of thymine and folic acid with the toxin.

Item Type:	Article
Uncontrolled Keywords:	Aflatoxins-; toxicity-; thymine-; folic-acid; poisoning-; susceptibility-
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology 600 Technology > 08 Food technology > 29 Microbiological food
Divisions:	Fermentation Technology and Bioengineering
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	31 Aug 2021 04:09
Last Modified:	31 Aug 2021 04:09
URI:	http://ir.cftri.res.in/id/eprint/8542

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