Fragments of obestatin as modulators of feed intake, circulating lipids,and stored fat

ShreeRanga, Nagaraj and Muthukumar, S. Peddha and Uma, V. Manjappara (2008) Fragments of obestatin as modulators of feed intake, circulating lipids,and stored fat. Biochemical and Biophysical Research Communications, 366. pp. 731-737.

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Abstract

Obestatin, shown to reduce feed intake and gain in body weight in rodents, is a very attractive candidate to be used against obesity. In this study, we aimed to investigate the relationship between the primary structure and activity of obestatin. Also of interest to us is a peptide of minimal length that closely mimics obestatin. Towards the same, we synthesized rodent obestatin and three overlapping fragments spanning residues 1–13, 6–18, and 11–23 of obestatin. These peptides subsequent to purification and characterization were tested upon adult male mice for their ability to reduce feed intake and gain in body weight. The N-terminal peptide (residues 1–13) mimicked obestatin the closest. The middle fragment (residues 6–18) significantly reduced epididymal fat without much altering feed intake or body weight.

Item Type:	Article
Uncontrolled Keywords:	Obestatin; Epididymal and perirenal fat
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 25 Peptide Chemistry
Divisions:	Dept. of Biochemistry Protein Chemistry and Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	20 Nov 2008 07:20
Last Modified:	29 Jan 2018 09:48
URI:	http://ir.cftri.res.in/id/eprint/8852

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