Antiplatelet Activity of Coriander and Curry Leaf Spices

Thrombosis, an important event in cardiovascular diseases,
can be fatal if platelet aggregation takes place in
the narrowed lumen of arteries, causing an impairment
of blood flow to the heart. Attempts have been made
to study the antiplatelet activity of leaf spice extracts,
as these are rich sources of natural antioxidants. Aqueous
extracts of coriander leaf and curry leaf were tested
on human platelets over a wide range of concentrations
with agonists like adenosine diphosphate (ADP)
(61 mM), epinephrine (76 mM), and collagen (0.005% in
0.1N acetic acid). Both these leaf spice extracts inhibited
human platelet aggregation. The IC50 values were 0.94,
0.65, and 0.58 mg for curry leaf and 0.55, 0.66, and
0.57 mg for coriander leaf with ADP, epinephrine, and
collagen, respectively. A decrease in the malondialdehyde
formed was used as a mechanism for accessing the function
of the cyclooxygenase pathway in arachidonic acid
metabolism at IC50 values of these extracts.