Mammalian safety of Decaleside II in the laboratory mouse

Rajashekar, Y. and Shivanandappa, T. (2014) Mammalian safety of Decaleside II in the laboratory mouse. Toxicology Reports, 1. pp. 969-972.

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Abstract

Decaleside II, a novel trisaccharide isolated from the edible roots of Decalepis hamiltonii, belongs to a new class of natural insecticides. We have evaluated the mammalian safety of Decaleside II in the laboratory mouse. Our results on acute and sub acute toxicity study suggest that Decaleside II is not toxic to the laboratory mice as there were no symptoms of toxicity or mortality up to 2400 mg/kg bw. Haematological profile was unaltered and serum profiles of enzymes were not significantly affected. The lack of toxicity of Decaleside is attributed to the 1,4 � linkage of the sugars which are easily hydrolyzed by the digestive enzymes such as glucosidases. The selective toxicity to insects and mammalian safety of Decaleside II makes them highly suitable for use as novel grain protectants of natural origin.

Item Type:	Article
Uncontrolled Keywords:	Decaleside II Mammalian safety Serum profile 1,4 alpha linkage Digestive enzymes
Subjects:	500 Natural Sciences and Mathematics > 10 Plants 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 26 Pesticide Chemistry
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	20 May 2016 10:38
Last Modified:	20 May 2016 10:38
URI:	http://ir.cftri.res.in/id/eprint/12197

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