Renoprotective Effect of Coccinia indica Fruits and Leaves in Experimentally Induced Diabetic Rats

Abignan Gurukar, M. S. and Mahadevamma, S. and Nandini, Chilkunda D. (2013) Renoprotective Effect of Coccinia indica Fruits and Leaves in Experimentally Induced Diabetic Rats. Journal of Medicinal Food, 16 (9). pp. 839-846.

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Abstract

Diabetic nephropathy is one of the secondary complications of diabetes mellitus that is marked by changes in extracellular matrix components leading to end-stage renal failure. Diet plays an important role in managing diabetes. In the present study, the effect of Coccinia indica consumption on diabetes-mediated kidney damage was determined. Both control and diabetic rats were fed with AIN-76 diet supplemented with C. indica fruits and leaves individually at 10% and 5%, respectively, for a period of 2 months. Various parameters, such as fasting blood glucose, urine sugar, albumin excretion, kidney index, and glomerular filtration rate, were ameliorated to various extents by the supplementation of C. indica in the diet. Additionally, diabetic rats fed with diet supplemented with C. indica fruits or leaves showed improvement in glucose tolerance compared to control diabetic rats. They also exhibited beneficial effects on key antioxidant enzymes of the kidney. Furthermore, an increase in laminin and fibronectin as a result of diabetes was alleviated in C. indica-fed rats. These results indicate that the consumption of C. indica is beneficial in partially containing diabetes-mediated deleterious effects on the kidney.

Item Type:	Article
Uncontrolled Keywords:	albumin excretion Coccinia indica diabetes mellitus extracellular matrix components kidney index
Subjects:	600 Technology > 01 Medical sciences > 04 Diabetes Mellitus 600 Technology > 08 Food technology > 24 Fruits
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	22 Sep 2016 12:48
Last Modified:	22 Sep 2016 12:48
URI:	http://ir.cftri.res.in/id/eprint/12316

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