Eugenol and n-3 Rich Garden Cress Seed Oil as Modulators of Platelet Aggregation and Eicosanoids in Wistar Albino Rats.

Raghavendra, R. H. and Akhilender Naidu, K. (2011) Eugenol and n-3 Rich Garden Cress Seed Oil as Modulators of Platelet Aggregation and Eicosanoids in Wistar Albino Rats. The Open Nutraceuticals Journal, 4. pp. 144-150.

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Abstract

Eugenol, the active principle of clove oil is a potent antioxidant and a well known anti-inflammatory agent. In an earlier study, we have reported the in vitro inhibition of human platelet aggregation and LTC4 formation in rat PMNL cells. In the present study, an attempt has been made to monitor the in vivo and in vitro modulation of platelet aggregation and eicosanoids (TXB2, LTC4) by eugenol and a-linolenic acid (ALNA) rich garden cress seed oil in adult Wistar rats. Feeding of Garden cress oil (GCO) supplemented diet to rats for 8 weeks moderately inhibited platelet aggregation induced by ADP and arachidonic acid (AA) at 14 and 7% respectively and also TXB2 levels at 10 and 32% in lung and spleen tissues. Oral feeding of eugenol at 40 mg/kg body weight for one week to GCO fed rats showed 20-30% inhibition of ADP and AA induced platelet aggregation and also TXB2 levels by ~ 50% in spleen. In an in vitro study, eugenol at 15.0 and 45.0

Item Type:	Article
Uncontrolled Keywords:	Eugenol, garden cress oil, n-3 fatty acids, platelet aggregation, TXB2, LTC4
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 17 Fatty Acid Chemistry 600 Technology > 09 Industrial oils, fats, waxes, gases > 03 Essential oils
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	27 Jun 2017 05:39
Last Modified:	27 Jun 2017 05:39
URI:	http://ir.cftri.res.in/id/eprint/12670

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