Neurotoxicity and Pattern of Acetylcholinesterase Inhibition in the Brain Regions of Rat by Bromophos and Ethylbromophos

Santhoshkumar, P. and Karanth, S. and Shivanandappa, T. (1996) Neurotoxicity and Pattern of Acetylcholinesterase Inhibition in the Brain Regions of Rat by Bromophos and Ethylbromophos. Fundamental and Applied Toxicology, 32. pp. 23-30.

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Abstract

Bromophos (Bp) and ethylbromophos (EBp) are two structur- merson et al., 1989). However, other studies have not shown ally homologous organophosphorus (OP) insecticides which show a clear difference in AChE inhibition in the brain regions wide differences in their toxicity as well as neurotoxic symptoms (Gupta et al., 1987a,b; Misulis et al., 1987). Detailed studies in the laboratory rat. EBp is 24-fold more toxic (LD50 = 91± 14 on OP insecticide homologs with regard to differential inhimg/ kg body wt) than Bp (LD50 ± 2218 { 195 mg/kg body wt) bition in the brain regions are not available. The objectives and only EBp produced characteristic tremors and lacrimation. of the present work were to investigate comparative effects In vivo cholinesterase inhibition was in the order plasma ú erythof the two OP homologs, Bp and EBp, on AChE inhibition rocytes ú brain. Experiments with equitoxic and equimolar doses in different brain regions and to identify the ‘‘sensitive’’ showed that EBp is a more potent anticholinesterase compound area(s) in the brain in relation to neurotoxicity. Further, we than Bp. Since IC50 values for the brain AChE were similar for both OPs, the target enzyme sensitivity was not a major factor in have also examined whether target enzyme (AChE) sensitive their differential toxicity. In vitro reactivation of serum ChE was it is a factor in the differential toxicity of methyl and ethyl significantly higher in the case of EBp than that of Bp. AChE in OP homologs. the brain regions showed differential inhibition in vivo. The brain stem AChE inhibition was least by Bp, whereas it was highest in the case of EBp. Both the OPs produced high AChE inhibition in the hippocampus. Differential inhibition of AChE in the brain Animals. Female albino rats (CFT–Wistar strain) weighing 200–250 regions and its consequent effects may be important factors in the differential neurotoxicity of Ops in the whole brain may be inadequate to understand the Neurotoxicity and Pattern of Acetylcholinesterase Inhibition in neurotoxicity of organophosphorus (OP) compounds the Brain Regions of Rat by Bromophos and Ethylbromophos. (Bajgar, 1972).

Item Type:	Article
Uncontrolled Keywords:	Neurotoxicity Acetylcholinesterase Inhibition Bromophos ethylbromophos
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Protectants and Infestation Control
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	26 Jun 2007 12:09
Last Modified:	28 Dec 2011 09:28
URI:	http://ir.cftri.res.in/id/eprint/1271

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