Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces cancer cell death via modulation of galectin-3 and surviving.

Mallikarjuna, S. E. and Dharmesh, Shylaja M (2018) Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces cancer cell death via modulation of galectin-3 and surviving. Carbohydrate Polymers, 186. pp. 402-410.

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Abstract

Swallow root pectic oligosaccharide fraction (SRO1) from swallow root pectic polysaccharide (SRPP) possessed a molecular size of 831 Da. Structural analysis revealed that it is a rhamnogalacturonan I type, bearing arabinogalactan side chain with β-D-(1→4) galactose along with α-L-Araf (1→5)-α-L-Araf (1→3) structure on α-D-GalAOAc-( 1→2)-α-L-Rha-(1→4)- linear backbone. β-D (1→4) linked galactose being the specific sugar for galectin-3, SRO1 had potentials in inhibiting galectin-3 mediated cancer progression. SRO1 inhibited galectin-3 mediated agglutination, in vitro, effectively with MIC of 1.08 μg/ mL and down regulated mRNA levels of galectin-3 (∼92%) along with its downstream key protein that inhibits apoptosis – survivin (∼78%) suggesting the capability of SRO1 in inhibiting galectin-3 mediated cancer promoting pathway. This is the first report, which highlights the inhibition of interplay of galectin-3 and survivin by a dietary pectic oligosaccharide.

Item Type:	Article
Uncontrolled Keywords:	SRO1 SRPP B16F10 cells Galectin-3 Survivin Metastasis
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 28 Polysaccharide Chemistry 600 Technology > 08 Food technology > 23 Vegetables > Swallow root
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	02 Jul 2018 09:38
Last Modified:	02 Jul 2018 09:38
URI:	http://ir.cftri.res.in/id/eprint/13551

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