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Zinc supplementation mitigates its dyshomeostasis in experimental diabetic rats by regulating the expression of zinc transporters and metallothionein.
Susmita, Barman and Pradeep, S. R. and Srinivasan, K. (2017) Zinc supplementation mitigates its dyshomeostasis in experimental diabetic rats by regulating the expression of zinc transporters and metallothionein. Metallomics, 9 (12). pp. 1765-1777.
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Metallomics Volume issue 2017 [doi 10.1039%2Fc7mt00210f] Barman, Susmita; Pradeep, Seetur R.; Srinivasan, K -- Zinc supplementation mitigates its dyshomeostasis in experimental diabetic rats by regula.pdf - Published Version Restricted to Registered users only Download (5MB) | Request a copy |
Abstract
Zinc depletion during diabetes projects a role for zinc nutrition in this condition. This study explored whether zinc supplementation annuls diabetes-induced zinc dyshomeostasis through modulation of zinc transporters and metallothionein. Groups of hyperglycemic rats were exposed for six weeks to supplemental zinc (5 or 10-times the normal level). Intracellular zinc concentration and zinc transporter and metallothionein expression levels in different tissues were analysed. Depleted zinc concentrations in different organs were restored by zinc supplementation. Zinc ions cross biological membranes with the aid of membrane proteins, belonging to zinc transporter families - ZIPs (responsible for the influx) and ZnTs (responsible for intracellular traffic/efflux). Up-regulated expression levels of zinc efflux proteins and influx proteins were beneficially modulated by zinc treatment, which also induced metallothionein expression in tissues to mitigate oxidative stress. Thus, zinc supplementation has a significant benefit in controlling zinc fluxes during diabetes, exerted through a protective influence on the modulation of the expression of zinc transporters and metallothionein.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Diabetes; Zinc dyshomeostasis; Tissue zinc distribution; Zinc excretion; Zinc supplementation; Zinc transporters; Metallothionein |
| Subjects: | 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus 600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 07 Feb 2019 04:20 |
| Last Modified: | 07 Feb 2019 04:20 |
| URI: | http://ir.cftri.res.in/id/eprint/13936 |
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