Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β.

Lalitha, N. and Sadashivaiah, B. and Ramaprasad, T. R. and Sridevi Annapurna, Singh (2020) Lectin rich horsegram protein and myricetin activates insulin signaling – A study targeting PTP1β. Journal of Functional Foods, 67. ISSN 1756-4646

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Abstract

Horsegram, a rich source of myricetin (Myr), exhibits an anti-hyperglycemic effect. We examined the individual and combinational effect of Myr and horsegram protein (HP) on protein tyrosine phosphatase 1β (PTP1β), and its effect on insulin signaling in high-fat-diet (HFD) and a single dose of streptozotocin (STZ) induced diabetic rat model. Myr, HP, and their combination, Myr + HP, were orally administered to diabetic animals for four weeks. Myr, HP, and Myr + HP were effective in reducing elevated blood glucose, HbA1c, fasting insulin, insulin resistance, oxidative stress markers, and proinflammatory cytokines. Myr ameliorated dyslipidemia and significantly reduced PTP1β activity; HP and Myr + HP were not as effective, although they suppressed the expression of PTP1β. Myr and HP treated groups had elevated levels of the phospho-insulin receptor (pIR), phospho-insulin receptor substrate1 (pIRS1), and phospho-Akt (pAkt), whereas, Myr + HP was not effective. Though myricetin and horsegram proteins ameliorate diabetic conditions, dietary intake of their combination reduced individual efficiency.

Item Type:	Article
Uncontrolled Keywords:	Fasting blood glucose level Horsegram protein Insulin sensitivity Myricetin Protein tyrosine phosphatase 1β
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 29 Protein Chemistry 600 Technology > 08 Food technology > 22 Legumes-Pulses
Divisions:	Dept. of Biochemistry Protein Chemistry and Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	23 Apr 2020 05:34
Last Modified:	23 Apr 2020 05:34
URI:	http://ir.cftri.res.in/id/eprint/14259

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