Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit alpha-amylase, alpha-glucosidase and DPP-IV activity in high fat and low dose streptozotocin-induced diabetic rat.

Arpitha, Das and Naveen, J. and Sreerama, Y. N. and Gnanesh Kumar, B. S. and Baskaran, V. (2021) Low-glycemic foods with wheat, barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) inhibit alpha-amylase, alpha-glucosidase and DPP-IV activity in high fat and low dose streptozotocin-induced diabetic rat. Journal of Food Science and Technology. ISSN 0022-1155 (Submitted)

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Abstract

Wheat, barley or wheat ? barley and herbs (Terminalia chebula, Terminalia bellerica and Emblica officinalis) based low-glycemic-index (low-GI) foods were developed and studied a-amylase, a-glucosidase and DPPIV inhibition property in vitro and in the streptozotocininduced diabetic rats. The GI of products ranged from 47 to 53 than control white bread (GI = 95). Total phenolic (20.1 ± 1 mg gallic acid/g dry wt.) and flavonoids (15.2 ± 1 mg quercetin/g dry wt.) were higher in wheat ? barley than barley (17.2 ± 1; 13.6 ± 2) and wheat (16.9 ± 1; 14.9 ± 2) products. The in vitro aamylase (4–10%), a-glucosidase (5–17%) and DPP-IV (3–26%) inhibition (IC50) of methanol extracts were higher than the aqueous extracts. The fasting blood glucose (50.85, 33.22 and 24.52%) and oral glucose tolerance (AUC = 32.1, 36.04, and 27.73%) was lower in barley, wheat, and wheat ? barley fed diabetic groups than diabetic control group (1571.5 ± 13.5 mg/dL/120 min). Feeding wheat, barley, and W ? B foods for 60 days inhibited the intestinal a-amylase (1.2, 1.1 and 1.5-folds), a-glucosidase (1.3, 1.2 and 1.7-folds) and DPP-IV (1.6, 1.5 and 2.1-folds) activity compared to diabetic control. Low- GI foods lower the systemic glucose level, inhibit the glycolytic enzymes and DPP-IV activity and hence desirable for diabetes management.

Item Type:	Article
Uncontrolled Keywords:	Cereals Herbs Antidiabetic Glycolytic enzymes Low-GI
Subjects:	600 Technology > 03 Agriculture > 04 Medicinal Plants 600 Technology > 08 Food technology > 18 Processed foods > 04 Functional foods 600 Technology > 08 Food technology > 21 Cereals
Divisions:	Dept. of Biochemistry Grain Science and Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	25 Nov 2021 09:20
Last Modified:	25 Nov 2021 09:20
URI:	http://ir.cftri.res.in/id/eprint/15088

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