Brown algae and barley-based anti-obesity food and its safety in C57BL6 mice.

Priya Prakash, Sharma and Vanajakshi, V. and Devendra, J. Haware and Baskaran, V. (2022) Brown algae and barley-based anti-obesity food and its safety in C57BL6 mice. Journal of Food Science and Technology, 59. pp. 4230-4243. ISSN 0022-1155

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Abstract

Brown algae have been considered a potential source of bioactives and used as a dietary supplement to manage obesity and its associated health complications. However, its effective use is limited due to heavy metals and microbial contamination, unawareness of health ben�efits and limited dietary exploitation. We developed, the Indian brown algae Padina tetrastromatica and barley�based anti-obesity food (AOF) and examined for microbial and heavy metal safety. Additionally, acute [0 (control), 50, 100, 200, 500 g AOF/kg diet] and sub-acute [0, 5, 50 g AOF/kg diet] doses of AOF were fed to C57BL6 mice and toxicity was examined. The physical, locomotory, hema�tological, biochemical parameters and histopathology were examined. Postprandial plasma and tissue levels of fucoxanthin and its metabolites were analyzed. Feeding AOF did not affect the general behavior, food and water intake, growth or survival of animals. Biochemical indices did not show any differences between AOF-fed and control groups. However, significantly lower levels of plasma cholesterol and triglycerides in groups fed 5 and 50 g of AOF/kg diet were observed. The post-mortem examination revealed no macroscopic/microscopic alteration in the vital organs. Overall, results validate that AOF is a safe and effective dietary supplement (even at higher doses of 500 g AOF/kg) to mitigate obesity.

Item Type:	Article
Uncontrolled Keywords:	Toxicity � Anti-obesity food � Heavy metals � Fucoxanthin
Subjects:	500 Natural Sciences and Mathematics > 08 Botanical sciences > 01 Botany > 01 Algae 600 Technology > 08 Food technology > 18 Processed foods 600 Technology > 08 Food technology > 21 Cereals > 02 Barley
Divisions:	Dept. of Biochemistry Food Safety Analytical Quality Control Lab
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	13 Sep 2022 09:24
Last Modified:	12 May 2023 09:22
URI:	http://ir.cftri.res.in/id/eprint/15744

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