Efficacy of a functional food ingredient from Ensete superbum Roxb. Cheesman peel in reducing the severity of ulcerative colitis in a murine model.

Nimisha, Sarah Mathew and Muthukumar, S. P. and Bettadaiah, B. K. and Negi, P. S. (2022) Efficacy of a functional food ingredient from Ensete superbum Roxb. Cheesman peel in reducing the severity of ulcerative colitis in a murine model. Food and Function, 13. pp. 3732-3745.

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Abstract

Ulcerative colitis is a recurrent inflammatory illness of the colon with an elevated risk of developing colon cancer. The drugs presently used to treat UC cause adverse effects and are limited to symptomatic treat�ments. To overcome these constraints, naturally derived novel alternative therapies are being tested. Ensete superbum Roxb. Cheesman (wild banana) is used as a folk medicinal plant to treat stomach aches, diarrhea, and dysentery. Previous research has shown that a peel dioxane (PD) fraction obtained from a ripe peel aqueous extract of E. superbum Roxb. Cheesman possesses in vitro antioxidant, anti-inflamma�tory and anti-colon cancer effects. Furthermore, it has been shown to alleviate 2,4,6-trinitrobenzene sul�fonic acid (TNBS) induced ulcerative colitis (UC) in rats. The current study intended to evaluate its efficacy as a functional dietary component added to cold pressed orange juice in colitic rats, and deduce the molecular processes involved in UC amelioration. The PD fraction in orange juice ameliorated colitis by modulating the oxidative stress and inflammatory parameters in the damaged tissue with improved healing activity as indicated by a lower disease activity index (DAI) score. The ameliorative effect was related to the inhibition of the nuclear factor-κB (NF-κB) signaling pathway by downregulating the expression levels of NFκBp65, TNF-α, IL-6 and IL-1β, followed by the recovery of epithelial barrier integ�rity. The ameliorating effects were statistically similar (p > 0.05) to those of the standard sulfasalazine treated population. The results suggest that PD fractions can be used as a new functional food and as an adjuvant to prevent IBDs due to their anti-colitic effect; however, it needs to be confirmed in clinical trials

Item Type:	Article
Uncontrolled Keywords:	Ulcerative colitis, Ensete superbum Roxb. Cheesman, functional food, ameliorative effect
Subjects:	600 Technology > 01 Medical sciences > 09 Human Physiology 600 Technology > 03 Agriculture > 04 Medicinal Plants 600 Technology > 08 Food technology > 18 Processed foods > 04 Functional foods
Divisions:	Dept. of Biochemistry Fruit and Vegetable Technology Plantation Products Spices and Flavour Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	24 Jan 2023 10:56
Last Modified:	24 Jan 2023 10:56
URI:	http://ir.cftri.res.in/id/eprint/15859

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