Targeting Dipeptidyl peptidase-4 (DPP4) by peptide inhibitors for the management of Type-2 diabetes and its complications.

Abdul, Majid (2022) Targeting Dipeptidyl peptidase-4 (DPP4) by peptide inhibitors for the management of Type-2 diabetes and its complications. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

The application of dietary bioactive peptides has increased in nutraceutical and pharmaceutical research to manage lifestyle diseases, including Type 2 Diabetes Mellitus (T2D) and its related complications. One of the key reasons for the postprandial chronic hyperglycemic condition during T2D is the early degradation of incretin hormones, by an enzyme Dipeptidyl peptidase-4 (DPP-4), which shows increased enzyme activity during diabetes. In this study, we generated the low molecular weight bioactive peptides from Sorghum bicolor seed proteins using gastrointestinal simulation model followed by membrane centrifugation.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	low molecular weight, bioactive peptides, Sorghum bicolor seed proteins, Dipeptidyl peptidase-4, Diabetes Mellitus
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 25 Peptide Chemistry 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus 600 Technology > 08 Food technology > 21 Cereals > 06 Sorghum
Divisions:	Molecular Nutrition
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	18 May 2023 07:09
Last Modified:	18 May 2023 07:09
URI:	http://ir.cftri.res.in/id/eprint/16401

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