Neuroprotective, lifespan, memory enhancing potential, and molecular docking studies of natural compound from Curculigo orchioides Gaertn.,: A study on Alzheimer’s disease model of Appl-GAL4 Drosophila melanogaster.

Pratap, G. K. and Pramod, G Nagaraju and Ananda, Danagoudar and Chandrashekhar, G. Joshi and Poornima Priyadarshini, C. G. (2022) Neuroprotective, lifespan, memory enhancing potential, and molecular docking studies of natural compound from Curculigo orchioides Gaertn.,: A study on Alzheimer’s disease model of Appl-GAL4 Drosophila melanogaster. South African Journal of Botany, 149. pp. 60-66.

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Abstract

Alzheimer’s (AD) is one of the most common age-related neurodegenerative diseases in the world. Currently it has affected about 33.9 million people and is estimated to triple over the next 5 years. The accumulation of amyloid-beta plaques in the neurons is one of the important characteristic features of AD which leads to the gradual decline of a person’s memory, learning and reasoning ability leading to difficulty in carrying out daily activities. Medicinal plants are the main ingredients of native medicines and have a major role in traditional health care. Of late, medicinal plants are being accepted widely because of fewer side effects compared to synthetic drugs. Moreover, they also meet the requirement of medicine necessary for increasing human pop�ulation. Medicinal plants play a crucial role in the development of new herbal drugs. Curculigo orchioides Gaertn., commonly known as Kali Musli or golden grass, is extensively utilised as a nutritive tonic for strength and treatment of asthma, skin diseases, neurodegenerative diseases, diarrhea, etc. To isolate and characterize the MS-1 compound from Curculigo orchioides Gaertn.,rhizome. The isolated compound was analysed by LC-MS, HPLC, FTIR, and 13 C &1 H��NMR and molecular docking studies. The neuroprotective effect of the MS-1compound was evaluated on the Appl-GAL4 model of D.melanogaster. The MS-1compound showed good neuroprotection, antioxidant activity and also increased the climbing activity and the lifespan of Drosophila. These results might explain the effect of MS-1 compound as a good neuroprotective agent. In the future, it can be used in making anti-Alzheimer drugs

Item Type:	Article
Uncontrolled Keywords:	Curculigo orchioides Gaertn. Appl-GAL4 Alzheimer's disease AChE-Ab complexes H and C NMR LCMS HPLC Moleculardocking studies
Subjects:	600 Technology > 01 Medical sciences > 09 Human Physiology 600 Technology > 03 Agriculture > 04 Medicinal Plants
Divisions:	Molecular Nutrition
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	22 May 2023 08:35
Last Modified:	22 May 2023 08:35
URI:	http://ir.cftri.res.in/id/eprint/16433

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