Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of the eye protective carotenoid lutein in rat model.

Veeresh, T. and Priyanka, Srirangam and Naveen, Jayapala and Baskaran, V. (2021) Lutein encapsulated oleic - linoleic acid nanoemulsion boosts oral bioavailability of the eye protective carotenoid lutein in rat model. Materials Today Communications, 28. p. 102522.

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Abstract

There is great interest in emerging colloidal delivery systems to enhance the water solubility and oral bioavailability of lutein, a hydrophobic carotenoid claimed to possess health benefits. The present study aimed to design lutein-enriched nanoemulsions with improved physicochemical properties and achieve various health benefits. The prepared lutein nanoemulsion was characterized and its bioavailability was examined in vitro (simulated gastrointestinal digestion) and in vivo. The mean size, PDI and zeta potential of the lutein nano�emulsion were 110 ± 8 nm, 0.271 and 36 ± 2 mV, respectively. Furthermore, TEM examination revealed that the particles are nanosized and spherical. Notably, the aqueous solubility of the nanoemulsion was 726-fold higher than that of free lutein. The composite nanoemulsion also showed exceptionally higher (87.4 %) in vitro bio�accessibility than nonencapsulated or free lutein (15 %). The in vivo bioavailability of lutein nanoemulsion (112.6 ng/mL) was much higher than that of nonencapsulated lutein (48.6 ng/mL) and mixed micelles (68.5 ng/ mL) and the tissue distribution pattern of lutein nanoemulsion showed higher lutein accumulation in the liver (2.80 and 1.70 fold) and eye (1.91 and 1.48 fold) compared to free lutein and mixed micelle-fed groups. These results suggested that oleic acid-linoleic acid composite nanoemulsions may be a promising delivery system for lutein and may help enhance the solubility, oral bioavailability and bioefficacy of lutein and could be used as an ingredient for the formulation of beverages or functional foods.

Item Type:	Article
Uncontrolled Keywords:	Lutein nanoemulsion Bioavailability In vitro bioaccessibility Simulated gastrointestinal digestion Bioefficacy
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	22 May 2023 09:22
Last Modified:	22 May 2023 09:22
URI:	http://ir.cftri.res.in/id/eprint/16436

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