![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Acute and subacute in vivo safety assessment of developed chitosan derivatives for food applications.
Punarvasu, T. P. and Harish Prashanth, K. V. (2023) Acute and subacute in vivo safety assessment of developed chitosan derivatives for food applications. Food Hydrocolloids for Health, 4. p. 100145.
![[img]](http://ir.cftri.res.in/style/images/fileicons/other.png) |
PDF
1-s2.0-S2667025923000304-main.pdf - Published Version Restricted to Registered users only Download (11MB) | Request a copy |
Abstract
The acute and subacute studies of two chitosan derivatives was conducted by oral administration on Swiss albino mice. Chitosan soluble derivatives were prepared by depolymerization method using potassium persulfate. 13C NMR data have revealed that Low Molecular Weight Chitosan (LMWC) has higher (~70%) ‘acetylated’ residues and Self Assembled Chitosan Microparticles (SAMC) consists of ‘deacetylated’ residues. For acute toxicity study, a single dose of two concentrations 2000 and 5000 mg/kg bw of the chitosan derivatives (LMWC, or SAMC) was given orally to healthy mice. Results indicated that the LD50 value for chitosan derivatives was greater than 5000 mg/kg bw. In the sub-acute toxicity studies, administration of concentrations 1000 and 2000 mg/kg bw dose of chitosan derivatives (repeated daily dose for 28 days) also did not reveal any toxicological changes in clinical observations, viz. relative organs, body weight, food consumption, biochemical parameters studied, antioxidant markers, and histopathological studies has been compared with control group. Together, present systematic study supports the oral administration of non-viscous and soluble chitosan derivatives (LMWC & SAMC) will have no toxicity may be safe to use in food and pharma applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Low molecular weight chitosan Self-assembly Sub-acute toxicity Safety Histopathology OECD |
| Subjects: | 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 27 Polymer Chemistry 600 Technology > 08 Food technology > 28 Meat, Fish & Poultry > Fish |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 06 Dec 2023 11:24 |
| Last Modified: | 06 Dec 2023 11:24 |
| URI: | http://ir.cftri.res.in/id/eprint/16779 |
Actions (login required)
 |
View Item |